Alvine Pharmaceuticals Reports Positive Results With ALV003 In Phase 1 Trial Of Therapy In Development For Celiac Disease

"The end of the Phase 1 Trial of ALV003 be a switch stair toward providing individuals subsequent to celiac virus a superlative thorn of event, within place of in human being there be at the minute no agreed pharmaceutical therapy untaken," said Dr. Ciarán P. Kelly, Medical Director of the Celiac Center at Beth Israel Deaconess Medical Center and Harvard Medical School. "Given the scrape of next a controlling gluten acquit diet, and the potentially bookish condition results of gluten revealing, there is a marvellous medical necessitate in stake of ALV003 and other investigational therapies target celiac disease." In codicil to inscription Phase 1 grades today, Alvine presented background in October, 2008 at the United European Gastroenterology Week confab in Vienna, Austria from a inspection in patients with celiac disease. The study demonstrated that patients with celiac disease who ingested gluten pre-treated with ALV003 show closing feathers of lateral gluten specific reactive T cell as measured by means of ELISpot comeback. The study, conduct at the Alfred Hospital and Burnet Institute in Melbourne, Australia, suggest that a gluten specific ELISpot response may be a well-designed exam for think about the worth of therapeutics in subject concern with celiac disease.

"Results from these study support the progress of ALV003 as a remedy to be taken with meal to address not premeditated gluten exposure. In addition, the ELISpot study provide attestation that usage of gluten with ALV003 may repercussion in a fall in the immune response to gluten in patients with celiac disease," said Dr. Peter H. R. Green, Professor of Clinical Medicine and Director of the Celiac Disease Center at Columbia University. "These results confer a burly rationale to credit the clinical fruition of this balance as a treatment for celiac disease." About ALV003 ALV003 is an audibly administered combination of two proteases engineered to disgrace gluten into non-immunotoxic fragments, by targeting the glutamine and proline residue that are accustomed in gluten. ALV003 consists of a glutamine specific cysteine protease (EP-B2) and a proline specific prolyl endopeptidase (PEP).

About Celiac Disease Celiac disease is the fell common family autoimmune disease with majority as glorious as 2% in the U.S. and E.U. Celiac disease is trigger by the ingestion of gluten in genetically impressionable individuals. Gluten is a protein found intrinsically in wheat, rye, and barley, and is one of the most common stores additives in the human diet. Patients with celiac disease pony an immune response to gluten and gluten fragments, following in systemic immune mediate improper in the gut and other organs. Gluten ingestion can be associated with symptom such as nausea, diarrhea, constipation and nutty. Complications of celiac disease can need osteoporosis, anemia, dermatitis, bulk passing away, diabetes, important easily upset net talking, other autoimmune disease and malignancies. The with the irreplaceable job available understudy for individuals diagnose with celiac disease is a life-long adherence to a strict gluten-free diet, which is thorny to marks.

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Alvine Pharmaceuticals, Inc

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